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the diagnosis and treatment of the liver, gallbladder, biliary tree and pancreas

Bile duct surrounded by scar tissue in a cirrhotic liver (20x). Image courtesy of Dr. Richard Levenson, CRI, Woburn, Massachusetts, USA

The diagnosis and treatment of the liver, gallbladder, biliary tree and pancreas

Changes in tissue structure can be indicative of liver disorders and other hepato-biliary diseases and is valuable for staging disease. Many of these changes can be observed in biopsy preparations using Nikon’s ergonomic Eclipse Ci clinical upright microscopes. Telepathology/cytology technologies also greatly assist in real-time assessment by pathologists in remote locations, in training, and archiving specimens. Nikon’s Digital Sight series cameras and DS-L3 imaging system enable clinics to implement telepathology with ease. Increasingly, advanced imaging techniques are employed using instruments such as Nikon’s Eclipse Ti inverted microscope, the Eclipse Ni upright microscope, the AZ 100 Multizoom upright zoom microscope and the powerful A1+/A1R+ confocal laser microscopes and A1 MP+ multiphoton microscope systems, together with specialised objectives to visualise specific cellular and molecular structures. In addition, these microscope systems are ideal for live-cell imaging to provide critical insight into the fundamental nature of cellular and tissue function. Fluorescent probes allow monitoring of protein expression, locating and tracking molecules and identification of intermolecular interactions. Multiple probes may be used simultaneously and identified with high resolution using spectral imaging capabilities. For research requiring molecular-level spatial resolution, the N-SIM and N-STORM super resolution microscope systems enable visualisation at nanoscopic levels – beyond the diffraction limit of conventional optical microscopes.

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