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Research Stereo Microscope

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Intelligent yet affordable manual zoom stereomicroscope provides brilliant images and unparalleled uniformity in fluorescence intensity.

Nikon's SMZ18 research stereomicroscope combines macro and micro imaging in one manual instrument for convenient, affordable viewing and manipulation of single cells to whole organisms. A high-performance fly-eye lens provides crystal-clear fluorescent images, with uniform brightness across the entire field of view. Using enhanced epi-fluorescence technology, the SMZ18 is better able to detect excitation light than conventional fluorescent stereomicroscopes, for improved S/N ratios and bright, high-contrast images, even in the low magnification range. Integrated intelligence allows SMZ18 to save imaging parameters along with the captured image as a convenient data file.

Key Features

Brightest Epi-fluorescence Imaging

Brightest Epi-fluorescence Imaging

The SMZ18 combines fly-eye technology, which uniformly illuminates the entire field of view, and a high S/N ratio along with increased transmission for incredibly bright fluorescence, even at low magnifications. This also minimizes photobleaching and phototoxicity, thus reducing harm to live cells and organisms.

Flexible Architecture Allows Full Customization

A wide range of digital imaging capabilities means that users can customize the SMZ18 to best suit their research needs.

Improved Signal-to-Noise Ratios

Improved Signal-to-Noise Ratios

Nikon’s newly developed optical system offers a drastic improvement in S/N ratio even at high magnifications.

The improved S/N ratio makes it possible to capture cell division, which is difficult using conventional stereomicroscopes, and samples with low excitation light.

Advanced Digital Imaging Capabilities

Access the Information you want Quickly and Easily
Easily obtain the information you need, such as Z drive position, zoom factor, objective lens, filter cube, and LED DIA brightness by using the Digital Sight series and NIS-Elements or Digital Sight series DS-L3 together with the microscope.

On-axis Imaging for Digital Images
Easily switch between stereo position (stereoscopic view) and mono position (on-axis view) when using the P2-RNI2 Intelligent Nosepiece by simply sliding the objective lens. Digital images with uncompromised clarity can be captured using the mono position.

NIS-Elements Imaging Software
Nikon’s flagship, cross-platform imaging, software can now be used with Nikon’s newest stereomicroscope systems. NIS-Elements enables a wide range of advanced digital imaging capabilities, easily from a PC.


Digital Sight DS-L4 Camera Control Unit
The DS-L4 is a tablet-style control unit with a large 10.1 inch touch display that can be used to quickly capture images without connecting to a PC. The scale bar automatically adjusts to accommodate changes in magnification. Optimal imaging parameters for each sample type and observation method can easily be set using the scene icons.

Detected observation condition/available control

◯ : Detection and control of observation condition possible
◎ : Detection of observation condition possible

  SMZ25 SMZ18
  • Motorized focus unit
  • Motorized epi-fluorescence light set (control box A)
  • Manual focus unit
  • Manual epi-fluorescence light set (relay box and control box B)
DS-L4 NIS-Elements DS-L4 NIS-Elements
Zoom magnification
Objective (with nosepiece)
Diascopic LED illumination stand (ON/OFF, light intensity control)
Fluorescence illuminator (light intensity control)
Filter cube changeover

For other combinations, please contact Nikon.

*With NIS-Elements F (Free package), functions above are not available. Use NIS-Elemsnts D/Br/Ar.

Wide Range of Available Accessories

Base Unit Options

Nikon has improved ease of use by moving the controls to the front of the base, including the brightness adjustment dial and on/off switch.

  • Fiber DIABase - Fiber DIA base features condenser lenses that can be switched between low and high magnifications. Furthermore, the Oblique Coherent Contrast (OCC) illumination system allows high contrast illumination.
  • Slim Bases -  The slimmer LED DIA Base and Plain Base help increase efficiency of sample manipulation by bringing the level of the sample closer to the table.

Focus Unit

The focus unit is combined with the base unit. Choose from either a manual or motorized focus unit.

SHR Plan Apo Series Objective Lenses

The SHR Plan Apo series features higher NA, wider field of view, and superior flatness and color aberration correction. These objective lenses can be seamlessly switched because all magnifications have the same parfocal distance. The new bayonet mount design allows lenses to be safely and easily removed.

SMZ Objectives


SMZ Tubes

Choose from two types of tilting trinocular tube and one type of low eyelevel trinocular tube. All tubes have a camera port for seamless integration with the Digital Sight series.

Nosepiece / Focus Mount Adapter

There is one type of nosepiece that can mount two objective lenses and two types of focus mount adapters for use with a single objective lens.


The stage features an XY stroke of 6x4 inches (150mm x 100mm) and can be attached to any of the bases, making it effective for capturing large images when used in combination with the imaging software NIS-Elements. A sliding stage and tilting stage are also available.Controller


SMZ Controller

Nikon offers a remote control unit that can be used to operate the microscope and capture images by hand. A footswitch is also offered, allowing the user to operate the microscope and capture images by foot, freeing the hands for sample manipulation.

Epi-fluorescence Light Sets

  • Motorized:The fluorescent turret can be operated using the remote control or imaging software NIS-Elements.
  • Manual:An easy-to-use manual model for Nikon’s newly developed high performance epic-fluorescence attachment.

Fiber Illuminator Sets

  • Flexible Double Arm Fiber Illumination Set:The direction and angle of illumination can be changed to suit the sample by making adjustments with these double arms. The fiber holder position can also be changed to obtain the optimal position for illuminating samples.
  • Manual Epi-Fluorescence Light Set:This ring fiber illumination set features an episcopic illumination unit that effectively captures images (can be used with 1x and 0.5x objective lenses).

Coaxial Illuminator

The coaxial light illuminator makes it possible to view light reflected from the surface of a sample, which is ideal for shooting shadow-less images of thick samples.

Ring LED Illuminator

This ring fiber illumination set features an episcopic illumination unit that effectively captures images (can be used with 1x and 0.5x objective lenses).

Darkfield Observation Accessory

Darkfield viewing is possible simply by attaching the darkfield unit to the base.

Polarizing Observation Accessory

The analyzer is attached to the objective and the polarizer to the base or stand to enable polarized viewing.

  1. Intended application of the product (for medical care)

    This product is intended for use in experiments of living cells and tissues and their examinations at hospitals and other medical facilities in the field of genetics, immunology, physiology, pharmacology, neurology, cellular biology and molecular biology.

    The bright-field, phase contrast, differential interference contrast or epi-fl microscopy is used to observe a sample (cell and tissue) in a culture vessel such as a Petri dish or fixed on a slide as the specimen.

    The product is classified as an in-vitro diagnostic medical device.
    The product is not intended for use for measurement.
    The scale on the focus handle and stage is an indicator to reproduce the position and does not guarantee the value of the thickness or length of a sample measure using this scale.

  2. Intended user

    It is intended for researchers and the medical professional and those who work on experimentations in the field of genetics, immunology, physiology, pharmacology, neurology, cellular biology and molecular biology.

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