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Inverted Microscope System

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Flexible specification inverted microscope configurable to meet your research needs

The Eclipse Ti-U inverted research microscope from Nikon is our universal model that can be configured for use with additional motorised components allowing you to build up a microscope to meet many of today’s demanding microscopy techniques. The Ti-U comes in a choice of two models with a standard three port model or expanded four port model which gives you access to a bottom port when your application demands you capture every single photon. The Eclipse Ti-U uses Nikon’s world-famous CFI60 optical system and a wide choice of objectives for bright field, dark field, fluorescence, phase contrast, DIC and modulation contrast microscopy techniques.

Key Features

High-speed Motorized Control and Acquisition

Multipoint snapshots of HeLa cells transiently expressing Venus-tubulin and mCherry-actin and stained with Hoechst33342 and DiD. (All in pseudo-color) Dr. Kenta Saito, Research Institute for Electronic Science, Hokkaido University and Dr. Takeharu Nagai, The Institute of Scientific and Industrial Research, Osaka University

The operational speeds of motorized components such as the nosepiece, fluorescence filters and stage have been greatly enhanced, allowing high-speed screening image capture during multi-dimensional experiments. Faster device movement and image acquisition reduce overall light exposure and subsequent photo-toxicity, leading to more meaningful data. The digital Controller Hub significantly increases motorized accessory speed by reducing communication overhead time between components, boosting total operation speed.


High-quality Phase Contrast Images using High NA Lenses

Phase Contrast

The revolutionary external phase contrast unit enables the use of high N.A. non-phase contrast objective lenses for phase contrast imaging by the use of an external phase ring.  As this external phase ring is not in the epi-fluorescence light path, users can capture both fluorescence images as well as phase contrast images without compromising on fluorescence tranmission.


Advanced Integration with Peripherals via NIS-Elements Imaging Software

Eclipse Ti-E 6D time-lapse Imaging System

Nikon's comprehensive imaging software NIS-Elements provides an integrated control of the microscope, cameras, components and peripherals. The intuitive GUI and efficient workflow make the programming of automated imaging sequences up to 6D (X, Y, Z, time, wavelength, multipoint) easy to perform.


Two-tiered Configuration Capability

Taking advantage of the Nikon Ti’s stratum structure, modules can be incorporated as two separate layers with multiple modules per layer. Using a dual layer configuration enables optimal filter configuration for each illumination module. This enables optimal filter selection and improves experimental accuracy whilst maintaining the highest acquisition speeds.

Two-tiered configuration

Multiport Design

The Ti-U has two built-in imaging ports* that can be dedicated to specific tasks, offering a flexible configuration at a high cost-to-performance ratio.

(* With Ti-U/B model with bottom port)


  1. Intended application of the product (for medical care)

    This product is intended for use in experiments of living cells and tissues and their examinations at hospitals and other medical facilities in the field of genetics, immunology, physiology, pharmacology, neurology, cellular biology and molecular biology.

    The bright-field, phase contrast, differential interference contrast or epi-fl microscopy is used to observe a sample (cell and tissue) in a culture vessel such as a Petri dish or fixed on a slide as the specimen.

    The product is classified as an in-vitro diagnostic medical device.
    The product is not intended for use for measurement.
    The scale on the focus handle and stage is an indicator to reproduce the position and does not guarantee the value of the thickness or length of a sample measure using this scale.

  2. Intended user

    It is intended for researchers and the medical professional and those who work on experimentations in the field of genetics, immunology, physiology, pharmacology, neurology, cellular biology and molecular biology.


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