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Prof. Staffan Strömblad, Ph.D.

Prof. Staffan Stromblad’s group at Karolinska Institutet

Researcher Interviews

Prof. Staffan Strömblad, Ph.D.

Staffan Strömblad Ph.D. is group leader at the prestigious Karolinska Institutet, Stockholm, Sweden, an institution that awards the Physiology Nobel Prize yearly. He is also the head of the Live Cell Imaging Facility (LCI), in which the Nikon Center of Excellence for live cell imaging is integrate.


A brief summary of research

Prof. Strömblad’s laboratory relies heavily on live cell imaging to produce outstanding scientific achievements in the fields of cancer biology and cell migration. Within his research group, Assistant Professor John G. Lock is leading and coordinating the Systems Microscopy Platform, implementing novel analytical approaches to unravel the wiring of cell migration. Systems Microscopy is a quantitative approach based on systematically imaging randomly migrating cells to generate multiparametric datasets that capture the heterogeneity of the biological system, combined with advanced mathematical data analysis (Lock and Strömblad, Exp Cell Res, 2010; Lock et al, 2014).

Why use Nikon Instruments systems?

Nikon A1 and A1R microscopes have been a fundamental tool to perform the required standardized, systematic live cell imaging experiments, leading to the very recent publication of elegant papers. These address the role of different levels of expression of the adhesion-related protein Talin in cell migration behavior (Kiss et al., Integr Biol, 2015), as well as the role of molecular-level Vinculin-mediated force transmission in the plastic modulation of adhesion complex dynamics (Hernandez-Varas et al., Nat Commun, 2015).

  • Lock JG, Strömblad S. “Systems microscopy: an emerging strategy for the life sciences”. Exp Cell Res. 2010 May 1. http://www.ncbi.nlm.nih.gov/pubmed/20381488
  • Lock JG, Mamaghani MJ, Shafqat-Abbasi H, Gong X, Tyrcha J, Strömblad S. “Plasticity in the macromolecular-scale causal networks of cell migration.” PLoS One/ 2014 Feb 28 http://www.ncbi.nlm.nih.gov/pubmed/24587399
  • Kiss A, Gong X, Kowalewski JM, Shafqat-Abbasi H, Strömblad S, Lock JG. “Non-monotonic cellular responses to heterogeneity in talin protein expression-level”. Integr Biol (Camb). 2015 May 22.  http://www.ncbi.nlm.nih.gov/pubmed/26000342
  • Hernández-Varas P, Berge U, Lock JG, Strömblad S. “A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime”. Nat Commun. 2015 Jun 25.  http://www.ncbi.nlm.nih.gov/pubmed/26109125

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