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Dr. Erik Manders

Dr Erik Manders

Researcher Interviews

Dr. Erik Manders

Dr. Erik Manders is assistant professor and operational manager of the Van Leeuwenhoek centre for advance microscopy at the Universiteit van Amsterdam.

Dr. Erik Manders focuses on the development of microscopy technology for live-cell imaging and has contributed greatly to the advance of biological imaging by developing “controlled light exposure microscopy” (CLEM) and the re-scan confocal microscopy (RCM) (view Biography).

A brief summary of research

Erik Manders studied in experimental physics (University of Amsterdam) and did a PhD at the University of Amsterdam in development and applications of multi-color confocal microscopy (1994). During post-doc positions Stockholm and Oxford he focused on building new microscopes and 3D-imaging of living cells. Back in Amsterdam, he patented his invention "Controlled Light Exposure Microscopy" (CLEM) and further developed this technology with his co-workers from the Academic Medical Centre (Amsterdam).

At the moment he is associate professor at the University of Amsterdam and operational manager of the Van Leeuwenhoek Centre for Advanced Microscopy (UvA). At this moment he leads a small research group and focuses on the development of super-resolution technology that can be used for live-cell imaging. Two techniques are now being developed in his group and find their way to industry and biological applications.

Re-scan Confocal Microscopy (RCM) is a new super-resolution technique that provides improved resolution and strongly improved optical sensitivity.  This improved confocal microscope is based on simple technology and is typically useful for biological applications where the combination of high resolution and high sensitivity is required.

The second technique is Multi-spot Structured Illumination Microscopy (MSIM) which is based on illumination of the sample with a dedicated pattern of spot lights. Interference of this spot-pattern with microscopic structures in the cell provides super-resolution information which can be extracted with image reconstruction techniques.

Together with biologists within and outside the institute, these new techniques are applied in biomedical research. Moreover, within the Nikon Centre of Excellence on Super-Resolution Microscopy the knowledge generated from these projects is transferred towards the industry.

Currently, he is developing the multi-spot structured illumination microscopy (MSMI). Combining his Nikon SIM system with a projection of a special pattern of spots and software with SR-information this new system can obtain a resolution above 120nm.

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