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Medical University of Graz / University of Graz

Mission

Nikon Instruments Europe has partnered with the Medical University of Graz and the University of Graz to open a new Center of Excellence for Superresolution Microscopy: Cells and Organelles. The center will combine Nikon’s technical expertise with the scientific expertise of the research groups to contribute to cutting edge cellular imaging in recent developments of molecular and biomedical research.

 

Area of Expertise

This partnership provides researchers of the Universities access to state-of-the art imaging equipment and Nikon technical expertise. In return, Nikon gains valuable feedback and insight from talented scientists using progressive research techniques in diverse research areas.

Univ.-Prof. Dr. Wolfgang Graier, Head of the Institute of Molecular Biology and Biochemistry, Medical University of Graz, works in the field of molecular and cellular physiology focusing on Ca2+ signalling, mitochondria, energy metabolism, aging, and the design of new fluorescence sensors.

Univ.-Prof. DI Dr. Sepp D. Kohlwein, Professor at the Institute of Molecular Biosciences, University of Graz, works in the field of yeast genetics and molecular biology on lipid metabolism and membrane assembly with focus on the investigation of lipid-associated disorders.

Due to the long tradition of the Medical University of Graz and the University of Graz in advanced light microscopy, there is also a keen focus on developing and adapting new imaging techniques that can be applied to the researcher's areas of expertise. That will allow for rapid advancements in both science and cutting-edge imaging technology.

Systems Available

A1Rsi with a Ti-E Inverted Microscope

The A1si is a powerful point scanning confocal microscope system suitable for a broad range of applications, particularly spectral resolution and rapid imaging. The A1R comes equipped with a unique hybrid scan head, incorporating both an ultra high-speed resonant scanner and a high-resolution galvano scanner, enabling simultaneous bleaching/photoactivation and acquisition. The enhanced spectral imaging capabilities feature acquisition of a 32-channel spectral image (512 x 512 pixels) with a single scan in 0.6 second. 512 x 32-pixel images can be captured at 24 fps.

 


N-SIM on a Ti-E Inverted Microscope

Using high frequency Structured Illumination, the Nikon N-SIM can achieve image resolution of 85nm, which was previously considered impossible with optical microscopes. Temporal resolution of 0.6 sec/ frame enables super-resolution time-lapse imaging of dynamic live cell events.


N-STORM Localization-based Super-resolution Microscope

N-STORM is a super-resolution microscope system that combines “STochastic Optical Reconstruction Microscopy” technology and Nikon's Eclipse Ti research inverted microscope. The N-STORM super-resolution microscope provides dramatically enhanced resolution that is 10 times that of conventional optical microscopes and enables molecular level understanding.


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