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Rheumatology
diagnosis and treatment of rheumatic diseases

Polarized image of monosodium urate crystals (present in the joint fluid of gout patients). Image courtesy of Edward Lieser.

Rheumatology studies diagnosis and treatment of rheumatic diseases

Rheumatism is any painful disorder affecting the loco-motor system including joints, muscles, connective tissues, soft tissues around the joints and bones and autoimmune diseases. Many of these diseases are now known to be disorders of the immune system, and rheumatology is increasingly the study of immunology. Available with both episcopic and diascopic illumination, Nikon’s upright polarising microscopes are ideal for synovial fluid analysis, ranging from the compact Eclipse Ci POL polarizing microscope to the quantitative LV100N POL polarizing microscope.
The Eclipse Ci can be equipped with sensitive color polarizing accessories for identification of uric acid crystals, ideal for gout and pseudo-gout tests. Because the characteristics of rheumatological disorders are best explained by immunology, advanced imaging techniques are increasingly being employed using microscopes such as Nikon’s Eclipse Ti inverted microscope, the Eclipse Ni upright microscope, the AZ100 Multizoom upright zoom microscope and the powerful A1+/A1R+ confocal laser microscopes and A1 MP+ multiphoton confocal microscope systems. The N-SIM and N-STORM super resolution microscope systems enable visualisation at nanoscopic levels – beyond the diffraction limit of conventional optical microscopes. In addition, many of these advanced microscope systems are ideal for live-cell imaging to provide critical insight into the fundamental nature of cellular and tissue function. Fluorescent probes allow monitoring of protein expression, locating and tracking molecules and identification of intermolecular interactions. Multiple probes may be used simultaneously and identified with high resolution using spectral imaging capabilities.


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