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the diagnosis and treatment of kidney diseases

Three dimensional volume rendering of a kidney imaged on Nikon’s A1 MP+ multiphoton system. Image courtesy of Frank Costantini, Ph.D. and Liza Pon, Ph.D., Columbia University Medical Center

Nephrology is the diagnosis and treatment of kidney diseases

Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. Nikon’s ergonomic Eclipse Ci clinical upright microscopes are ideal for urinalysis and biopsy examination for definitive diagnosis and disease staging and monitoring of acquired conditions such as systemic vasculitides and autoimmune diseases, as well as congenital or genetic conditions such as polycystic kidney disease. Increasingly, advanced imaging techniques are employed using systems such as Nikon’s Eclipse Ti inverted microscope, the Eclipse Ni upright microscope, the AZ 100 Multizoom upright zoom microscope and the powerful A1+ /A1R+ confocal laser microscopes and A1 MP+ multiphoton confocal microscopes systems, together with specialised objectives to visualise specific cellular and molecular structures. In addition, these microscope systems are ideal for live-cell imaging to provide critical insight into the fundamental nature of cellular and tissue function. Fluorescent probes allow monitoring of protein expression, locating and tracking molecules and identification of intermolecular interactions. Multiple probes may be used simultaneously and identified with high resolution using spectral imaging capabilities.  The N-SIM and N-STORM super resolution microscope systems enable visualisation at nanoscopic levels – beyond the diffraction limit of conventional optical microscopes.

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