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Cardiovascular Research
the study of the cardiovascular system with the aim of the detection, prevention and treatment of disease

Anopheles gambiae (mosquito) heart (100x). Image courtesy of Jonas King Vanderbilt, University Department of Biological Sciences, Nashville, USA

Cardiovascular research studies the cardiovascular system with the aim of the detection, prevention and treatment of disease

Molecular and genetic approaches have defined the cellular and molecular interactions that drive the formation of the heart and blood vessels and many of the genes that govern these processes have been identified. In addition, improving understanding of developmental and stem cell biology may someday permit repair of damaged tissues. Nikon’s advanced imaging systems including the Eclipse Ti inverted microscope, Eclipse Ni upright microscope, AZ100 Multizoom microscope and C2+ confocal microscope, as well as the powerful, fully automated A1+/A1R+ confocal laser microscopes and A1 MP+ multiphoton confocal microscope system, together with Nikon’s specialised objectives, enable the visualisation of specific cellular and molecular structures. In addition, these advanced microscope systems are ideal for live-cell imaging to provide critical insight into the fundamental nature of cellular and tissue function. Fluorescent probes allow monitoring of protein expression, locating and tracking molecules and identification of intermolecular interactions. Multiple probes may be used simultaneously and identified with high resolution using spectral imaging capabilities. Stem cell culture requires the carefully controlled conditions provided by the Nikon IM-Q and CT BioStation time-lapse incubator imaging systems, which promote consistent and healthy cell populations and enable cell growth in culture to be easily monitored.  Nikon’s N-SIM and N-STORM super resolution microscope systems facilitate visualisation at nanoscopic levels – beyond the diffraction limit of conventional optical microscopes.

Imaging Challenges

How do I overcome fast movement in cardiovascular research?

Cardiovascular research is notoriously difficult due to its weak signal and fast movement. Nikon’s solution to this is the A1R+ confocal, which is ideal for very fast sensitive imaging.


In imaging, how do I overcome weak signal?

Optical sectioning can significantly improve signal-to-noise ratios.  For example, by using a high-sensitivity, back-thinned EM-CCD camera and total internal reflection fluorescence microscopy (TIRFm), one can visualize single fluorescent molecules near the coverslip.  For example, using TIRF, one can visualize and track viruses that are being endocytosed at the cytoplasmic membrane

Laser TIRF System (motorized)

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