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the investigation of how mechanical forces interact with the structure and function of biological systems

Filamentous actin and microtubules (structural proteins) in mouse fibroblasts (cells) (1000x). Image courtesy of Dr. Torsten Wittmann, The Scripps Research Institute, San Diego, USA

Biomechanics plays a fundamental role in the function of sub-cellular processes to tissue and organ development.  In gaining a greater understanding of the mechanical behaviour of single cells, tissues and organs, researchers are able to advance the field of tissue engineering, as well as develop improved treatments for a wide array of pathologies, including neurological, musculoskeletal, and cardiovascular problems, to orthopaedics, dentistry and ophthalmology.  Nikon provides a variety of imaging tools ranging from macro-level to nano-scale level for investigating the mechanical properties of cells, tissues, and organs, either biological, or engineered hybrids of biological and synthetic components.  At the macro end of the spectrum, Nikon’s SMZ stereomicroscopes and AZ100 Multizoom microscope provide easy-to-use yet powerful systems that can provide micro-level information.  The A1R+ and A1R-MP+ confocal and multiphoton microscopes provide powerful tools examining tissues and organs at molecular and cellular levels.  The N-SIM and N-STORM super-resolution microscopes provide nanoscopic resolution.  The Eclipse Ti microscope, which provides the foundation for many of these advanced imaging systems, has a flexible, open structure that enables easy incorporation of custom tools that can be used to perturb the mechanical properties of the sample.

Imaging Challenges

On matrix-like structures, how do I overcome working distance issues?

Nikon’s CFI range of objectives offers long working distance lenses for all techniques.

CFI Achromat Series

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