Nikon N-SIM Super-Resolution Microscope System

Key Features

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Nearly Double the Resolution of Conventional Optical Microscopes

N-SIM nearly doubles the resolution of conventional optical microscopes by combining “Structured Illumination Microscopy” technology licensed from UCSF with Nikon’s renowned CFI Apo TIRF 100x oil objective lens (N.A. 1.49).


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Time Resolution of 0.6 sec/frame, the Fastest in the Industry

N-SIM provides the fastest imaging capability in the industry, with a time resolution of 0.6 sec/frame, effective for live-cell imaging.


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TIRF-SIM Imaging Technique

The newly developed TIRF-SIM illumination technique enables Total Internal Reflection Fluorescence (TIRF) observation with higher resolution than conventional TIRF microscopes and gives more detailed structural information near the cell membrane.


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3D-SIM Capable

The new 3D-SIM illumination technique has the capability of optical sectioning of specimens, enabling the visualization of more detailed cell structures at higher spacial resolutions up to 20μm in thickness.


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