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Research Papers

Earthworm production of luminescent quantum dots

December, 2012

In recent years, semiconductor quantum dots have been found to be superior in various medical and biological imaging applications

In recent years, semiconductor quantum dots have been found to be superior in various medical and biological imaging applications. However, to make them compatible with biological systems is challenging and often reduces the optical quality of the...

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Products: A1R-A1 Confocal

New insights into LVH

November, 2012

Left ventricular hypertrophy is a maladaptive response to cardiac insults such as hypertension, damage, or aging, and predisposes to heart failure and sudden death.

Left ventricular hypertrophy is a maladaptive response to cardiac insults such as hypertension, damage, or aging, and predisposes to heart failure and sudden death. Remediation of the hypertrophic phenotype at the early stages of the disease impro...

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Products: NIS-Elements Microscope Imaging Software, CFI Plan Apochromat VC Series, A1R-A1 Confocal

Studying the blood brain barrier in Alzheimer’s

June, 2012

The blood-brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of endothelial cells, maintains homeostasis of the brain.

The blood-brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca2+ homeostasis and breakdown of the BBB have been implicated in the pathogenes...

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Products: CFI Apochromat TIRF Series, Eclipse Ti, N-SIM Super-Resolution

Additional fascin function in filopodia

March, 2012

Filopodia are dynamic membrane extensions generated by bundles of F-actin that are involved in numerous biological processes.

Filopodia are dynamic membrane extensions generated by bundles of F-actin that are involved in numerous biological processes. One of the most widely studied proteins critical for the formation of filopodia is the evolutionarily conserved actin-bin...

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Products: CFI Plan Fluor Series, Eclipse Ti, A1R-A1 Confocal

New insights into DNA repair

March, 2012

DNA within the nucleus of cells can be damaged by normal metabolic processes and environmental factors, such as exposure to UV light, other forms of radiation, and certain environmental chemicals. DNA repair processes exist within cells to repair...

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Products: Laser TIRF System

Galectins – newly identified danger receptors for invading bacteria

March, 2012

Damaged or unwanted cellular components are normally broken down into basic molecules within the lysosomes of cells for recycling. This process, known as ‘autophagy’, has many functions, one of which is to rid cells of bacterial infection. The eff...

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Products: Eclipse Ti

Cancer cells ‘move out’ to escape regulatory neighbours

March, 2012

Cancer is the name given to illnesses that involve the growth of tumours, which can develop from any cell type in the body. The development of a tumour starts when just one cell, or a small group of cells, starts to multiply uncontrollably. Geneti...

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Products: A1R-A1 Confocal, Eclipse C1 Plus Confocal

New hope for hyaline cartilage repair

February, 2012

The repair of hyaline cartilage injury or degeneration with hyaline rather than fibrocartilage is a challenging clinical problem and regeneration of hyaline cartilage using autologous stem cell tra...

Hyaline cartilage is found at the joint surface of many bones, where it helps to cushion and protect the bone surfaces. Hyaline cartilage does not have a blood supply or nerve supply and consequently has a limited capacity for growth and repair –...

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Products: BioStation CT

Nuclear pores – an unknown role in mitosis?

January, 2012

The cell nucleus is encapsulated within its own membrane, separating the contents of the nucleus from the rest of the cell. Within the membrane, however, there are hundreds of pores, allowing the p...

The pores are known as ‘nuclear pore complexes’ (NPCs) and are composed of distinct protein sub-complexes or ‘nucleoporins’ with specific locations and functions. Some are involved in anchoring the pore to the cell membrane while others mediate th...

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Products: NIS-Elements Microscope Imaging Software, N-SIM Super-Resolution

SIM expands resolution of live cell imaging New article

October, 2011

Three-dimensional (3D) structured-illumination microscopy (SIM) can double the lateral and axial resolution of a wide-field fluorescence microscope but has been too slow for live imaging.

Three-dimensional (3D) structured-illumination microscopy (SIM) can double the lateral and axial resolution of a wide-field fluorescence microscope but has been too slow for live imaging. Here Shao et al apply 3D SIM to living samples and record w...

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Products: N-STORM Super-Resolution, CFI Plan Apochromat VC Series

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